HYPERTHERMIA RADIO-BIOLOGICAL RATIONALE Hyperthermia (HT), heating tumors in the range 41-43°C, is a powerful radio and chemosensitizer. The effectiveness of HT as well as its safety, in combination with radiotherapy and chemotherapy, has already been proven in phase III clinical trials [1,3], particularly in patients with very large or very advanced stages of cancer and recurrent tumors. HT enhances the effect of radiotherapy on the tumor, without additional toxicity for nearby healthy tissue, by multiple synergistic mechanisms.
HT enhances the effectiveness of radiotherapy by inhibiting the repair of DNA damage. [2,4,5,6]
HT increases tissue perfusion resulting in reoxygenation, thereby reducing hypoxia and increasing radiosensitivity. [2,6,7] With regard to chemotherapy, hyperthermia targets its action within the heated tumor region without aggravating systemic toxicity. [8] Local hyperthermia has also been shown to be capable of inducing systemic anti- tumor immune responses. [1]
HT selectively kills radioresistant hypoxic tumor cells. [2]
Clinical data show a significant hyperthermia-induced reduction of the α/β ratio, a.o. for recurrent breast cancer, head and neck cancer, and cervical cancer. This can be used to effectively optimize clinical dose-fractionation schedules.
The hyperthermic enhancement of the α and β parameters can vary per tumor type and is strongly temperature-dependent
Higher temperature for reoxygenation and more direct cell killing for an effective thermodose escalation
SHORT TIME INTERVAL
Achievable as the units allow for a short preparation time and ultrafast and precise Hyperthermia treatment delivery.
Automatic focusing at tumor coordinates and optimal matching with heated tissue.
Short preparation time of the patient set-up and dedicated tools for applicator positioning as well as the collimation of the center axis of the beam of the applicator with the center of the GTV/PTV.
Superior SAR homogeneity and maximum power deposition in the target result in a high dose escalation.
Dedicated tools in full compliance with the guidelines of the European Society of Hyperthermic Oncology (ESHO) guarantees high level, quality hyperthermia treatment over time.
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